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Table 3 Results of parameter estimation using CSUKF with and without the informed prior

From: A unified framework for estimating parameters of kinetic biological models

   

CSUKF without informed prior

CSUKF with informed prior

Parameter name

Original value

 

Mean

Std. Dev.

Mean

Std. Dev.

Ki1Fru

1.00

 

1.00

0.010

1.00

0.0100

Ki2Glc

1.00

 

1.00

0.009

1.00

0.0100

Ki3G6P

0.10

NI

0.67

1.460

0.16

0.0080

Ki4F6P

10.00

NI

0.63

0.850

6.26

1.1600

Ki6Suc6P

0.07

NI

0.45

0.770

0.25

0.0010

Ki6UDPGlc

1.40

 

0.32

0.400

0.14

0.0005

Vmax6r

0.20

NI

0.34

0.670

0.07

0.0003

Km6UDP

0.30

NI

4.73

3.450

4.69

0.0550

Km6Suc6P

0.10

NI

5.97

4.580

3.49

0.0100

Ki6F6P

0.40

NI

0.65

1.060

0.93

0.0050

Vmax11

1.00

 

0.28

0.190

1.03

0.0200

Km11Suc

100.00

NI

21.43

21.820

104.64

2.1200

  1. NI - Non-identifiable parameter.
  2. The mean and standard deviation are from 50 repetitions. For each of the iteration, the initial values for the parameters were initialized to random values in the range of 0 to 1, with the same initial values used for both cases.