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Table 5 Estimation result and standard deviation of the 29 parameters with and without informed priors

From: A unified framework for estimating parameters of kinetic biological models

  

Without informed prior

With informed prior

Parameter name

Actual value

Mean

Std. Dev.

Mean

Std. Dev.

p_degradation_rate

0.8

0.72

0.27

0.85

0.05

rbs1_strength

3.9

3.33

1.41

3.98

0.23

rbs2_strength

5.0

4.82

2.18

5.94

0.33

rbs3_strength

5.0

4.31

1.56

5.13

0.32

rbs4_strength

1.0

1.29

0.81

1.46

0.29

rbs5_strength

5.0

3.77

1.56

5.23

0.31

rbs6_strength

5.0

4.55

1.64

5.03

0.28

pro1_strength

3.0

2.94

0.15

3.04

0.05

pro2_strength

8.0

6.66

2.58

5.85

0.47

pro3_strength

6.0

9.14

4.43

7.12

0.68

pro4_strength

8.0

1.50

1.87

2.93

1.78

pro5_strength

3.0

3.46

0.80

3.03

0.07

pro6_strength

3.0

3.27

0.54

3.27

0.03

v1_Kd

1.0

1.40

1.62

1.54

0.18

v1_h

4.0

2.98

2.36

2.54

0.92

v2_Kd

1.0

1.17

0.74

1.87

0.15

v2_h

2.0

3.32

2.09

3.74

1.28

v3_Kd

0.1

0.61

0.31

0.56

0.18

v3_h

2.0

2.99

2.20

4.05

0.34

v4_Kd

10.0

7.17

3.10

8.04

1.12

v4_h

4.0

2.97

2.06

2.49

0.42

v5_Kd

1.0

2.16

1.52

2.22

0.41

v5_h

1.0

1.27

0.29

1.20

0.08

v6_Kd

0.1

0.64

0.57

0.28

0.02

v6_h

2.0

5.55

3.07

3.20

0.39

v7_Kd

0.1

0.48

0.28

0.26

0.02

v7_h

2.0

5.34

3.03

2.78

0.35

v8_Kd

0.2

2.14

2.40

0.41

0.30

v8_h

4.0

1.12

0.50

1.77

0.33

  1. The mean and standard deviations are from 50 runs. For each run the parameters were initialized to small random values between 0 and 1. The same set of initial values was used for both cases, with and without the informed prior.