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Figure 4 | BMC Bioinformatics

Figure 4

From: Systematic computation with functional gene-sets among leukemic and hematopoietic stem cells reveals a favorable prognostic signature for acute myeloid leukemia

Figure 4

Prognostic analysis of patients with cytogenetically normal AML, based on DNM identified gene-set pairs. Kaplan–Meier plots of survival analysis on stratified samples with better outcome (green) or worse outcome (red). The Relative Effect Analysis with Gene-Set-Group Pairs (RXA-GSP) calculated a prognostic indicator by comparing three LSC- representative gene-sets (30 genes) with three normal control gene-sets (166 genes, Additional file 4: Table S2). The normalized FAIME.5 profiles are used. In each sub-panel, top bars mark the simulated p-values from which we estimated the empirical p-value for the actually observed log-rank p-value, the vertical line marked with an arrow. A RXA-GSP indicator I of less than 1 significantly indicates worse prognosis in the training cohort (GSE12417, Panel A) of cytogenetically normal AML patients and in two validation cohorts (GSE14468 and TCGA, Panels B and C) of cytogenetically normal AML patients.

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