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Table 1 Active miRNA-TF-gene regulatory pathways in obesity

From: Identification of active miRNA and transcription factor regulatory pathways in human obesity-related inflammation

Active TF-miRNA regulatory pathway

Number of known AD genes and miRNAs

Pathway length

CR value

p-value

FDR

hsa-miR-193b → ETS1 → TNF-α

3

3

1

0

0

hsa-miR-193b → ETS1 → NFKB1

3

3

1

0

0

A → FLI1 → hsa-let-7a → MYC → hsa-miR-20b → STAT3 → B → TNF-α

8

15

0.533

8.78E-10

0.000486716

A → MYC → hsa-miR-29b → SP1 → TP53 → EGFR → B → TNF-α

8

15

0.533

8.78E-10

0.000486716

A → FLI1 → hsa-let-7a → MYC → hsa-miR-20b → STAT3 → B → NFKB1

8

15

0.533

8.78E-10

0.000486716

A → MYC → hsa-miR-29b → SP1 → TP53 → EGFR → B → NFKB1

8

15

0.533

8.78E-10

0.000486716

C → hsa-miR-29b → SP1 → TNF

8

15

0.533

8.78E-10

0.000486716

C → hsa-miR-29b → SP1 → RELA

8

15

0.533

8.78E-10

0.000486716

C → hsa-miR-22 → MAX → hsa-miR-193a

8

15

0.533

8.78E-10

0.000486716

C → hsa-miR-29b → SP1 → RBP4

8

15

0.533

8.78E-10

0.000486716

D → FLT1 → hsa-let-7a

8

15

0.533

8.78E-10

0.000486716

C → hsa-miR-29b → SP1 → VEGFA

8

15

0.533

8.78E-10

0.000486716

C → hsa-miR-29b → SP1 → SERPINE1

8

15

0.533

8.78E-10

0.000486716

C → hsa-miR-29b → SP1 → REL

8

15

0.533

8.78E-10

0.000486716

C → hsa-miR-29b → SP1 → CCL2

8

15

0.533

8.78E-10

0.000486716

D → STAT1 → CCL2

8

15

0.533

8.78E-10

0.000486716

C → hsa-miR-29b → SP1 → TP53

8

15

0.533

8.78E-10

0.000486716

E → TNF

8

15

0.533

8.78E-10

0.000486716

E → NFKB1

8

15

0.533

8.78E-10

0.000486716

F → FLI1 → hsa-let-7a → MYC → hsa-miR-20b → STAT3 → G → TNF

8

15

0.533

8.78E-10

0.000486716

F → MYC → hsa-miR-29b → SP1 → TP53 → EGFR → G → TNF

8

15

0.533

8.78E-10

0.000486716

F → FLI1 → hsa-let-7a → MYC → hsa-miR-20b → STAT3 → G → NFKB1

8

15

0.533

8.78E-10

0.000486716

F → MYC → hsa-miR-29b → SP1 → TP53 → EGFR → G → NFKB1

8

15

0.533

8.78E-10

0.000486716

  1. A for hsa-miR-204 → SNAI2 → hsa-miR-200c → JAG1 → hsa-miR-145.
  2. B for hsa-miR-21 → IL-1β → hsa-miR-9 → ETS1.
  3. C for SPI1 → IL1B → hsa-miR-9 → ETS1 → has-miR-146a → EGFR → hsa-miR-21 → JAG1 → .
  4. hsa-miR-145 → FLI1 → hsa-let-7a → MYC.
  5. D for SPI1 → IL1B → hsa-miR-9 → ETS1 → TFAP2A → MYC → hsa-miR-29b → SP1 → TP53 → .
  6. EGFR → hsa-miR-21 → JAG1 → hsa-miR-145.
  7. E for TP63 → JAG1 → hsa-miR-145 → FLI1 → hsa-let-7a → MYC → hsa-miR-29b → SP1 → TP53 → .
  8. EGFR → hsa-miR-21 → IL1B → hsa-miR-9 → ETS1.
  9. F for hsa-miR-124 → SNAI2 → hsa-miR-200c → JAG1 → hsa-miR-145.
  10. G forhsa-miR-21 → IL1B → hsa-miR-9 → ETS1.
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BMC Bioinformatics

ISSN: 1471-2105

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