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Table 1 Active miRNA-TF-gene regulatory pathways in obesity

From: Identification of active miRNA and transcription factor regulatory pathways in human obesity-related inflammation

Active TF-miRNA regulatory pathway Number of known AD genes and miRNAs Pathway length CR value p-value FDR
hsa-miR-193b → ETS1 → TNF-α 3 3 1 0 0
hsa-miR-193b → ETS1 → NFKB1 3 3 1 0 0
A → FLI1 → hsa-let-7a → MYC → hsa-miR-20b → STAT3 → B → TNF-α 8 15 0.533 8.78E-10 0.000486716
A → MYC → hsa-miR-29b → SP1 → TP53 → EGFR → B → TNF-α 8 15 0.533 8.78E-10 0.000486716
A → FLI1 → hsa-let-7a → MYC → hsa-miR-20b → STAT3 → B → NFKB1 8 15 0.533 8.78E-10 0.000486716
A → MYC → hsa-miR-29b → SP1 → TP53 → EGFR → B → NFKB1 8 15 0.533 8.78E-10 0.000486716
C → hsa-miR-29b → SP1 → TNF 8 15 0.533 8.78E-10 0.000486716
C → hsa-miR-29b → SP1 → RELA 8 15 0.533 8.78E-10 0.000486716
C → hsa-miR-22 → MAX → hsa-miR-193a 8 15 0.533 8.78E-10 0.000486716
C → hsa-miR-29b → SP1 → RBP4 8 15 0.533 8.78E-10 0.000486716
D → FLT1 → hsa-let-7a 8 15 0.533 8.78E-10 0.000486716
C → hsa-miR-29b → SP1 → VEGFA 8 15 0.533 8.78E-10 0.000486716
C → hsa-miR-29b → SP1 → SERPINE1 8 15 0.533 8.78E-10 0.000486716
C → hsa-miR-29b → SP1 → REL 8 15 0.533 8.78E-10 0.000486716
C → hsa-miR-29b → SP1 → CCL2 8 15 0.533 8.78E-10 0.000486716
D → STAT1 → CCL2 8 15 0.533 8.78E-10 0.000486716
C → hsa-miR-29b → SP1 → TP53 8 15 0.533 8.78E-10 0.000486716
E → TNF 8 15 0.533 8.78E-10 0.000486716
E → NFKB1 8 15 0.533 8.78E-10 0.000486716
F → FLI1 → hsa-let-7a → MYC → hsa-miR-20b → STAT3 → G → TNF 8 15 0.533 8.78E-10 0.000486716
F → MYC → hsa-miR-29b → SP1 → TP53 → EGFR → G → TNF 8 15 0.533 8.78E-10 0.000486716
F → FLI1 → hsa-let-7a → MYC → hsa-miR-20b → STAT3 → G → NFKB1 8 15 0.533 8.78E-10 0.000486716
F → MYC → hsa-miR-29b → SP1 → TP53 → EGFR → G → NFKB1 8 15 0.533 8.78E-10 0.000486716
  1. A for hsa-miR-204 → SNAI2 → hsa-miR-200c → JAG1 → hsa-miR-145.
  2. B for hsa-miR-21 → IL-1β → hsa-miR-9 → ETS1.
  3. C for SPI1 → IL1B → hsa-miR-9 → ETS1 → has-miR-146a → EGFR → hsa-miR-21 → JAG1 → .
  4. hsa-miR-145 → FLI1 → hsa-let-7a → MYC.
  5. D for SPI1 → IL1B → hsa-miR-9 → ETS1 → TFAP2A → MYC → hsa-miR-29b → SP1 → TP53 → .
  6. EGFR → hsa-miR-21 → JAG1 → hsa-miR-145.
  7. E for TP63 → JAG1 → hsa-miR-145 → FLI1 → hsa-let-7a → MYC → hsa-miR-29b → SP1 → TP53 → .
  8. EGFR → hsa-miR-21 → IL1B → hsa-miR-9 → ETS1.
  9. F for hsa-miR-124 → SNAI2 → hsa-miR-200c → JAG1 → hsa-miR-145.
  10. G forhsa-miR-21 → IL1B → hsa-miR-9 → ETS1.