Test

Units

Validation

N

λ

σ
_{
λ
}

f
_{
p
}

\({\sigma _{f_{p}}}\)


CAT

AT

–

–

1845

1.990

0.013

0.167

0.001

CAT

RSU

All

–

1845

1.900

0.013

0.163

0.002

CAT

RSU

Pairs

Cluster

1322 (661p)

0.853

0.008

0.044

0.001

CAT

RSU

Pairs

Vicinity

1254 (627p)

0.846

0.007

0.044

0.001

CAT

RSU

Groups

Cluster

1845 (661g)

0.921

0.006

0.047

0.001

CAT

RSU

Groups

Vicinity

1845 (627g)

0.921

0.009

0.046

0.001

CAT

RSU

Clusters

–

1845 (14c)

0.918

0.006

0.046

0.001

MCAT^{(2)}

RSU

Pairs

Cluster

1322 (661p)

0.832

0.008

0.044

0.001

MCAT^{(2)}

RSU

Pairs

Vicinity

1254 (627p)

0.828

0.010

0.043

0.001

MCAT^{(2)}

RSU

Groups

Cluster

1845 (661g)

1.005

0.011

0.050

0.001

MCAT^{(2)}

RSU

Groups

Vicinity

1845 (627g)

1.001

0.011

0.050

0.001

MCAT^{(2)}

RSU

Clusters

–

1845 (14c)

1.004

0.009

0.050

0.001

MCAT^{(1)}

AT

Pairs

Cluster

1322 (661p)

1.007

0.009

0.050

0.001

MCAT^{(1)}

AT

Pairs

Vicinity

1254 (627p)

1.007

0.011

0.050

0.001

MCAT^{(1)}

AT

Groups

Cluster

1845 (627g)

1.007

0.012

0.051

0.001

MCAT^{(1)}

AT

Groups

Vicinity

1845 (627g)

1.008

0.010

0.050

0.001

MCAT^{(1)}

AT

Clusters

–

1845 (14c)

1.000

0.007

0.050

0.001

LRmds

LRT

7 PCs

–

1845

1.201

0.019

0.078

0.001

LRmds

LRT

14 PCs

–

1845

1.006

0.009

0.051

0.001

LRmds

LRT

28 PCs

–

1845

1.017

0.009

0.052

0.001

 Given are means and standard errors of the inflation factor λ and falsepositive rates f
_{
p
} from ten iterations of 1845 individuals and ∼44,900 SNPs. The nominal error level is α=0.05. The abbreviations in the second column are: AT asymptotic test, RSU resampling simulation within units (99,999 cycles), LRT likelihood ratio test. Column N shows the number of individuals included and in brackets the number of pairs p, groups g and clusters c.