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Table 5 Comparison of top ranking associations between different stratification methods

From: Novel genetic matching methods for handling population stratification in genome-wide association studies

ID

chr:pos

P CAT

\(\text {P}_{\text {LR-mds13}}^{\text {[54]}}\)

\(\text {P}_{\text {{LR-pca07}}}^{\text {[55]}}\)

\(\text {P}_{\text {{MLMA}}}^{\text {[56]}}\)

P MCAT-gv

  

λ =1 . 087

λ =1 . 027

λ =1 . 021

λ =0 . 998

λ =1 . 044

rs13320534

3:46171700

7.35e-8

2.32e-7

5.22e-7

2.17e-7

4.63e-6

rs936939

3:45986623

9.85e-7

1.36e-6

2.20e-6

2.40e-6

1.55e-5

rs9967637

19:57250898

1.04e-6

6.50e-6

1.24e-5

1.96e-6

4.96e-5

rs17650960

15:27999442

1.84e-6

7.93e-5

9.67e-5

5.33e-5

3.81e-5

rs10902222

11:810882

1.89e-6

2.76e-5

1.14e-5

1.04e-5

4.16e-5

rs1992102

3:21280562

2.80e-6

1.55e-6

1.22e-6

2.93e-6

2.38e-2

rs2962492

5:39568609

7.54e-6

3.72e-6

4.19e-6

7.08e-6

1.08e-6

rs4673251

2:204114244

1.70e-5

6.90e-6

1.13e-5

2.03e-5

8.57e-2

rs16844699

3:103879674

4.00e-5

6.04e-5

6.04e-5

3.50e-4

1.50e-5

kgp9470129

3:141298124

5.30e-5

3.70e-5

2.67e-5

2.20e-5

1.34e-5

rs8073498

17:7569698

1.32e-4

1.66e-3

1.08e-3

6.90e-4

1.36e-5

rs3094078

6:30224970

3.16e-3

5.85e-8

5.00e-7

3.05e-2

1.28e-2

  1. The indices of the P-values refer to the type of test: CAT test without any stratification method, LR-mds13/LR-pca07 for logistic regression with 13 MDS/7 PCA covariates, MLMA stands for mixed linear model association and MCAT-gv for our modified CAT test with group unit and vicinity validation.