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Figure 4 | BMC Bioinformatics

Figure 4

From: EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib

Figure 4

Comparison of the WT EGFR-drug complex and mutant-drug complex structures. (A) and (B) display the WT EGFR and the mutant structure delT751_I759insS with gefitinib. (C) and (D) show the WT structure and the mutant dulA767_V769 with erlotinib. (E-H) present the corresponding solvent-excluded molecular surfaces of (A) to (D), and the drug binding pockets can be seen very clearly. In (A) to (D), the mutant sites are shown in magenta while the original sites are presented in blue. In addition, drugs are colored green.

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BMC Bioinformatics

ISSN: 1471-2105

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