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Table 4 Distribution of mutation types and the number of patients by mutation position

From: EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib

Mutation position

Number of occurrences

Number of mutation types

Number of patients

Percentage of all mutation types

Percentage of all the patients

Exon 18

≤3

14

19

12.5%

15.18%

2.02%

4.89%

>3

3

27

2.68%

2.87%

Exon 19

≤3

26

38

23.21%

32.14%

4.03%

43.41%

>3

10

371

8.93%

39.38%

Exon 20

≤3

25

34

22.32%

25.89%

3.61%

6.05%

>3

4

23

3.57%

2.44%

Exon 21

≤3

18

21

16.07%

17.86%

2.23%

44.48%

>3

2

398

1.79%

42.25%

Others

≤3

10

11

8.93%

8.93%

1.17%

1.17%