A frequency distribution of interactions by experiment type and organism was analyzed. Histogram showing numbers of interactions by type of experimental system. Major contributions shown in (A) and a smaller scale of contributions shown in (B). Code abbreviations are as follows: NR, Not reported; AC, Affinity Capture; NG, Negative Genetic; Y2H, Yeast-two-hybrid; PE, Phenotypic Enhancement; SL, Synthetic Lethality; SGD, Synthetic Growth Defect; DR, Dosage Rescue; PS, Phenotypic Suppression; PG, Positive Genetic; RC, Reconstituted Complex; Co-P, Co-purification; SR, Synthetic Rescue; BA, Biochemical Activity. PCA, Principal Components Analysis; Co-F, Co-fractionation; Co-CS, Co-crystal Structure; Co-L, Co-localization; DL, Dosage Lethality; FW, Far Western; SH, Synthetic Haploinsufficiency; DGD, Dosage Growth Defect; Prot, Protein/Peptide; FRET. (C) Histogram of interactions by organism type.