TY - JOUR AU - Tournoud, Maud AU - Larue, Audrey AU - Cazalis, Marie-Angelique AU - Venet, Fabienne AU - Pachot, Alexandre AU - Monneret, Guillaume AU - Lepape, Alain AU - Veyrieras, Jean-Baptiste PY - 2015 DA - 2015/03/28 TI - A strategy to build and validate a prognostic biomarker model based on RT-qPCR gene expression and clinical covariates JO - BMC Bioinformatics SP - 106 VL - 16 IS - 1 AB - Construction and validation of a prognostic model for survival data in the clinical domain is still an active field of research. Nevertheless there is no consensus on how to develop routine prognostic tests based on a combination of RT-qPCR biomarkers and clinical or demographic variables. In particular, the estimation of the model performance requires to properly account for the RT-qPCR experimental design. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-015-0537-9 DO - 10.1186/s12859-015-0537-9 ID - Tournoud2015 ER -