Channel extraction in a transmembrane protein.(a) Mechanosensitive Channel of Large Conductance (MscL, PDB id 2OAR). (b) The path network. (c) Widest path tree. (d) Pruned widest path tree. (e) Pores between top 10 boundary nodes in the network. (f) Transmembrane pores between top 5 interior and 5 exterior nodes. (g) Top ranked transmembrane pore shown using the skin surface (yellow). Other pores are shown for context.