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Table 1 Comparison of features supported in different channel extraction tools

From: CHEXVIS: a tool for molecular channel extraction and visualization

  CHEXVIS MOLE CAVER MOLAXIS POREWALKER
Computation of channels leading to internal molecular sites Yes Yes Yes Yes No
Automatic suggestion of internal sites using CSA Yes Yes Yes No No
Channels to multiple internal sites Yes Yes Yes No No
Filtering of similar channels No Yes Yes No No
Computation of pores Yes Yes No Limited Only transmembrane pores
Computation of transmembrane pores Yes No No Limited Yes
Multiple transmembrane pores Yes No No No No
Ranking of pores Yes No No No Not applicable
Computation of physico-chemical properties Yes Yes No No No
Interactive visualization of physico-chemical properties Yes No No No No
Conservation profile Yes No No No No
User Interface Web-server Web-server and GUI GUI Web-server Web-server
Interactive visualization of channels Yes Yes Yes No No
Good default parameters Yes Yes Yes Limited Yes
Computation speed Reasonable Fast Reasonable Reasonable Slow
PyMOL export Yes Yes Yes No No
PyMOL plugin No Yes Yes No No