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Table 3 Performance comparison on blind tests

From: MAESTRO - multi agent stability prediction upon point mutations

Method Data set Validation Pearson’s ρ σ (kcal/mol)
mCSMa SP1 5-fold Positionc 0.54 1.23
MAESTRO SP1 5-fold Positionc 0.67 1.12
mCSMa SP1 5-fold Proteinc 0.51 1.26
MAESTRO SP1 5-fold Proteind 0.63 1.17
mCSMa SP1 351d Blind Position 0.67 1.19
DUETb SP1 351d Blind Position 0.71 1.13
MAESTRO SP1 351e Blind Position 0.71 1.16
  1. aResults derived from Pires et al. [14], supplementary material. bResults derived from Pires et al. [15]. c5-fold cross validation on position level. All mutations of a certain mutation site are either in the test or training set. d5-fold cross validation on protein level. All mutations of a certain protein are either in the test or training set. eBlind test on a subset of the SP1 data set, provided by Pires et al. [14]. The set includes 351 mutants, whose positions are not in the remaining training set.