Method
|
Data set
|
Validation
|
Pearson’s
ρ
|
σ
(kcal/mol)
|
---|
mCSMa
| SP1 | 5-fold Positionc
| 0.54 | 1.23 |
MAESTRO | SP1 | 5-fold Positionc
| 0.67 | 1.12 |
mCSMa
| SP1 | 5-fold Proteinc
| 0.51 | 1.26 |
MAESTRO | SP1 | 5-fold Proteind
| 0.63 | 1.17 |
mCSMa
| SP1 351d
| Blind Position | 0.67 | 1.19 |
DUETb
| SP1 351d
| Blind Position | 0.71 | 1.13 |
MAESTRO | SP1 351e
| Blind Position | 0.71 | 1.16 |
-
aResults derived from Pires et al. [14], supplementary material. bResults derived from Pires et al. [15]. c5-fold cross validation on position level. All mutations of a certain mutation site are either in the test or training set. d5-fold cross validation on protein level. All mutations of a certain protein are either in the test or training set. eBlind test on a subset of the SP1 data set, provided by Pires et al. [14]. The set includes 351 mutants, whose positions are not in the remaining training set.