Characteristics of six classes of differentially-targeted genes. (A) The classification of genes based on whether evidence suggests that the regulatory interactions targeting those genes are activating, repressive, or both. (B) Enriched Biological Process Gene Ontology terms (FDR < 0.1) associated with at least one of these six classes; we only included categories with at least 100 gene annotations. FDR significance is shown as a color with darker colors representing more significant enrichment. (C) Potential angiogenesis biomarkers that belong to each of the six classes of genes. Biomarkers differentially-expressed between the subtypes at an FDR < 0.1 are noted in red or blue based on whether they are more highly expressed in the angiogenic or non-angiogenic subtypes, respectively.