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Figure 6 | BMC Bioinformatics

Figure 6

From: SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering

Figure 6

Signalling network of the putative breast cancer genes. The top-ranked genes that were detected on the breast cancer dataset were shown to be primary involved in the PI3K and the MAPK pathways. Genes are coloured green when they were classified as putative tumour suppressor genes (TSG scores ≥20) or in red when classified as putative oncogenes (OG scores ≥20 and TSG scores <20). The genes indicated in grey were not found to be significant by SomInaClust. Mutation frequencies and scores (OG score and TSG score respectively) are indicated below each gene. Arrows indicate stimulation, while bar-headed lines indicate inhibition.

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