A comparison between the results of  and the grouping methods on HIV data. The gray histogram represents the distribution of the (− log10-transformed) SMA p-values obtained by . Each of the first 15 blocks selected by the proposed approach (left panel) and the first 15 blocks selected by the haplotype association method (right panel) are represented by a colored horizontal segment ranging from the smallest to the largest SMA p-value of the block. Vertical black segments indicate SMA p-values of each SNP in these LD blocks. Vertical lines highlight the significance threshold used in  (dashed line) and the standard (non multiplicity-corrected) level of 0.05 (dash-dotted line).