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Figure 4 | BMC Bioinformatics

Figure 4

From: Multi-class BCGA-ELM based classifier that identifies biomarkers associated with hallmarks of cancer

Figure 4

The genes that are involved in various cellular activities as indicated by iReport® analysis of the cancer vs. normal data analysis of 92 candidate genes (selected by BCGA-ELM) are displayed inside a wheel here. This figure was consolidated from several figures (given separately in the supplement) in order to show all cell activities in the same figure. Genes that are involved in cellular activities such as signalling, metabolism, growth, apoptosis, survival and proliferation, disease specific interaction and signalling pathways are listed here. This wheel displays the most important 52 candidate genes, where different colours and size of genes indicate various properties. The blue and green colours on the outside of the big circle represent interactions and pathways. The purple markings are for different processes and the orange outer circles are for different diseases. Genes are grouped under three major circles for diseases, interaction pathways and processes as indicated by light grey background circles. The size of the genes indicates the number of diseases/molecular functions/processes they are associated with. Gene circles are coloured according to their expression levels, which range between −3.304 to 1.637, where blue is for lower values and orange for higher values. The small blue circles on the south-east corner of the circular gene symbols indicate that these genes have isoforms. There are 103 pathways involving 20 differentially expressed genes (DEGs), 341 processes involving 40 DEGs and 79 diseases involving 29 DEGs. Some of these are illustrated here and fully listed in Additional file 1: Tables ~ S5 and S6. Genes related to particular types of cancers that are highlighted on the left of the figure are circled in red. APOPA1, NOTCH2, B2M and VEGFC seem to play major roles in these cancers. Genes responsible for cell death and survival are also given here.

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