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Figure 5 | BMC Bioinformatics

Figure 5

From: Multi-class BCGA-ELM based classifier that identifies biomarkers associated with hallmarks of cancer

Figure 5

The top six of twelve biomarkers are listed in this table, with their family classification, such as transporters, growth factors, enzymes or regulators. Each biomarker is related to multiple cancers, with the top three biomarkers are related to almost all but one of the 14 cancers. The degree of filling of the circles denotes the number of processes in which the gene is involved in. The genes represented as filled circles, in the last column, under biomarker applications indicate the processes or disease related evidence, such as diagnosis, efficacy, disease progression, prognosis and safety. It can be seen that one biomarker can be active in multiple cancer classes, with APOA1 involved with all 13 cancers, except CNS. Similarly VEGFC is related to all but pancreatic cancer, while YWHAZ is related to all but ovarian cancer. These biomarkers are useful for diagnosis or determining the efficacy of drugs, while some of them are unspecified. Other colour coding in this figure are similar to those described in Figure 4.

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