From: Multi-class BCGA-ELM based classifier that identifies biomarkers associated with hallmarks of cancer
Data | Names of selected genes | Biomarkers | Hallmarks of Cancer |
---|---|---|---|
Breast - multiclass | CYC1, CYP2A6, DNASE1L3, EEF1D, EVI2A, GPM6B, HAS1, ICAM3, LAD1, LASP1, LEP, LMO4, LOC54157, LTBR, NAT1, PFKFB4, POU2F2, PPP1R1A, RBP1, TCEAL1, TDRD9, TIMP4 | APOE, APOH, BMP7, CALB2, CLU, COL4A3, EGF, IL4, IL13, ITGAV, LEP, LGALS3BP, LTC4S, MAPK1, MED21, MTOR, PPARG, PTK2, RBP1, SLC29A1, SMAD4, STAT5B, TGFB1, THY1, TIMP4, TLR4, TNF, TREM1 | Cell morphology, hematological system development and function ,cell-to-cell signalling and interaction, cell death and survival, cell-mediated immune response, cellular movement, cellular compromise, DNA replication, recombination, and repair, cell-mediated immune response. |
Leukemia - multiclass | PHF15, SPTAN1, FOXI1, MPO, APOC1, CD33, PTX3, LSS, ZYX, ATBF1, WIT1 | APOC1, CEBPA, JUNB, MPO, NOTCH3, PROC, ZYX | Hematological system development and function, immune cell trafficking, inflammatory response, tissue development, cellular function and maintenance, cell death and survival, cell morphology, tissue morphology, cell-to-cell signalling and interaction, cell-to-cell signalling and interaction, cellular function and maintenance, inflammatory response. |
CNS - binary | RPS23,TAGLN2, MORC3, BNC1, CSF2, MCFD2, GTF2B, CORO2A, IGF2BP3, UCHL1, EEF1B2, CNR2, CSN1S1, ITIH3, (3 unknowns ) | CCL2, CCL3L3, CD28, CD44, CDKN1A, CSF2, ETS1, FASLG, HTT, IGF2BP3, IL2, IL6, IL15, IL18,STAT3, TLR2, TNF, TREM1, UCHL1 | cell cycle arrest, cell death and survival, cellular compromise, cell-mediated immune response, cell-to-cell signalling and interaction, cellular development, cellular growth and proliferation, angiogenesis, cellular movement. |
DLBCL - binary | CIRBP, NID2, TRIB2, RPA2, TALDO1, CD28, ECH1, IQGAP2, CD37, CRYAA, ZFP36L1, PON1, CCR1, YWHAH, HLA-A (3 unknowns) | B2M, CALR, CCL5, CD28, CSF2, CCR1, CD28, CD37, CSF2, FLNA, GATA3, HLA-A, IFNG, IL2, IL5, IL2RG, OPRD1, PDCD1, PPARD, PTGER4, SLC7A5, TRAF2, YWHAH | cell-to-cell signalling and interaction, hematological system development and function, immune cell trafficking, inflammatory response, cell death and survival, cellular assembly and organization, cell cycle arrest, cell death and survival, DNA replication, recombination, and repair, cell death and survival, cellular assembly and organization, cell cycle arrest, cell death and survival, DNA replication, recombination, and repair, cell death and survival, cell morphology survival, cell morphology. |