Skip to main content

Table 2 Selected Genes, biomarkers and activities related to hallmarks of cancer, as identified by IPA®, for four of the eight data sets are given here

From: Multi-class BCGA-ELM based classifier that identifies biomarkers associated with hallmarks of cancer

Data Names of selected genes Biomarkers Hallmarks of Cancer
Breast - multiclass CYC1, CYP2A6, DNASE1L3, EEF1D, EVI2A, GPM6B, HAS1, ICAM3, LAD1, LASP1, LEP, LMO4, LOC54157, LTBR, NAT1, PFKFB4, POU2F2, PPP1R1A, RBP1, TCEAL1, TDRD9, TIMP4 APOE, APOH, BMP7, CALB2, CLU, COL4A3, EGF, IL4, IL13, ITGAV, LEP, LGALS3BP, LTC4S, MAPK1, MED21, MTOR, PPARG, PTK2, RBP1, SLC29A1, SMAD4, STAT5B, TGFB1, THY1, TIMP4, TLR4, TNF, TREM1 Cell morphology, hematological system development and function ,cell-to-cell signalling and interaction, cell death and survival, cell-mediated immune response, cellular movement, cellular compromise, DNA replication, recombination, and repair, cell-mediated immune response.
Leukemia - multiclass PHF15, SPTAN1, FOXI1, MPO, APOC1, CD33, PTX3, LSS, ZYX, ATBF1, WIT1 APOC1, CEBPA, JUNB, MPO, NOTCH3, PROC, ZYX Hematological system development and function, immune cell trafficking, inflammatory response, tissue development, cellular function and maintenance, cell death and survival, cell morphology, tissue morphology, cell-to-cell signalling and interaction, cell-to-cell signalling and interaction, cellular function and maintenance, inflammatory response.
CNS - binary RPS23,TAGLN2, MORC3, BNC1, CSF2, MCFD2, GTF2B, CORO2A, IGF2BP3, UCHL1, EEF1B2, CNR2, CSN1S1, ITIH3, (3 unknowns ) CCL2, CCL3L3, CD28, CD44, CDKN1A, CSF2, ETS1, FASLG, HTT, IGF2BP3, IL2, IL6, IL15, IL18,STAT3, TLR2, TNF, TREM1, UCHL1 cell cycle arrest, cell death and survival, cellular compromise, cell-mediated immune response, cell-to-cell signalling and interaction, cellular development, cellular growth and proliferation, angiogenesis, cellular movement.
DLBCL - binary CIRBP, NID2, TRIB2, RPA2, TALDO1, CD28, ECH1, IQGAP2, CD37, CRYAA, ZFP36L1, PON1, CCR1, YWHAH, HLA-A (3 unknowns) B2M, CALR, CCL5, CD28, CSF2, CCR1, CD28, CD37, CSF2, FLNA, GATA3, HLA-A, IFNG, IL2, IL5, IL2RG, OPRD1, PDCD1, PPARD, PTGER4, SLC7A5, TRAF2, YWHAH cell-to-cell signalling and interaction, hematological system development and function, immune cell trafficking, inflammatory response, cell death and survival, cellular assembly and organization, cell cycle arrest, cell death and survival, DNA replication, recombination, and repair, cell death and survival, cellular assembly and organization, cell cycle arrest, cell death and survival, DNA replication, recombination, and repair, cell death and survival, cell morphology survival, cell morphology.