Figure 9
From: Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism
A comparison of antagonists (magenta) in inactive states (pink) and agonists (teal) in active states (cyan) of Class A GPCRs: (A, B) rhodopsin, (C, D) adenosine A2A, (E, F) β2-adrenergic, (G, H) muscarinic acetylcholine M2, (I, J) P2Y purinoceptor 12. Only side-chains on TM6 and TM7 that make covalent or H-bonds with antagonists/agonists are displayed. H-bonds shown as black lines, calculated with CHIMERA [68]. Agonists typically make more H-bonds with TM6/7 than respective antagonists.