Figure 1

ROC curves. ROC curves of the developed COS and MWM measures, and of the NC method against the SD ⁻ dataset (panel a), the SD ⁺ dataset (panel b) and the OB dataset (panel c). For each panel, the left plots correspond to the full ROC curves and the right plots to a zoomed in subsection along the x axis. C O S _O1, C O S _O2, M W M _O1 and M W M _O2 are evaluated with weighting (w) or without. The influence of the kinase family in the SD ⁺ dataset on the sequence similarity based method (NC) is clearly seen in panel b.