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Table 2 Summary of studies with association between the 27 selected miRNAs and heart disease

From: Principal component analysis-based unsupervised feature extraction applied to in silico drug discovery for posttraumatic stress disorder-mediated heart disease

miRNAs

Ref.

Description

miR-451

[39]

Upregulated in heart due to ischemia

miR-22

[40]

Elevated serum levels in patients with stablechronic systolic heart failure

miR-133

[41]

Downregulated in transverse aortic constrictionand isoproterenol-induced hypertrophy

miR-709

[42]

Upregulated in rat heart four weeks after chronicdoxorubicin treatment

miR-126

[43]

Association with outcome of ischemic andnonischemic cardiomyopathy in patients withchronic heart failure

miR-30

[44]

Inversely related to CTGF in two rodent modelsof heart disease, and human pathological leftventricular hypertrophy

miR-29

[45]

Downregulated in the heart region adjacent toan infarct

miR-143

[46]

Molecular key to switching of the vascular smoothmuscle cell phenotype that plays a critical role incardiovascular disease pathogenesis

miR-24

[47]

Regulates cardiac fibrosis after myocardial infarction

miR-23

[48]

Upregulated during cardiac hypertrophy

miR-378

[49]

Cardiac hypertrophy control

miR-125

[50]

Important regulator of hESC differentiation to cardiacmuscle(potential therapeutic application)

miR-675

[51]

Elevated in plasma of heart failure patients

let-7

[52]

Aberrant expression of let-7 members incardiovascular disease

miR-16

[53]

Circulating prognostic biomarker in critical limbischemia

miR-26

[54]

Downregulated in a rat cardiac hypertrophy model

miR-669

[55]

Prevents skeletal muscle differentiation in postnatalcardiac progenitors