Table 5 Summary of studies with association between heart disease and genes selected by CPCAFE
Gene | RefSeq mRNA | miRNAs | Heart disease association ( P -values from the Gendooserver) |
|---|---|---|---|
Fabp3 | NM_010174 | miR-709 | Cardiomegaly (0.031) |
Cox4i1 | NM_009941 | miR-709 | Cardiac output, low (5×10−4) |
Atp5g1 | NM_001161419 | miR-29a/b-3p, | Cardiomyopathies (1.5×10−3) |
| Â | Â | miR-16 | Â |
Cox6a2 | NM_009943 | miR-23a/b-3p | Heart disease (1.3×10−3); Cardiomyopathies (2.3×10−3);Heart failure (5.0×10−3) |
Aldoa | NM_001177307 | miR-16 | Cardiomyopathy, dilated (2.0×10−3) |
Cox5a | NM_007747 | miR-26a-5p | Cardiomyopathies (5.4×10−3); Myocardial ischemia(7.4×10−4) |
Myl2 | NM_010861 | miR-1983 | Heart defects, congenital (4.9×10−48); Cardiomyopathy, dilated (5.2×10−21); Cardiomegaly (1.1×10−17); Heart failure (2.1×10−9) |
Myl3 | NM_010859 | miR-691 | Heart defects, congenital (1.1×10−7); Cardiomegaly(1.2×10−4); Myocardial infarction (2.4×10−4); Heart septal defects, ventricular (6.9×10−4) |
Tcap | NM_011540 | miR-207 | Cardiomyopathy, dilated (1.1×10−8); Cardiomyopathy, hypertrophic (1.7×10−3); Heart defects, congenital(6.0×10−3); Heart failure (1.2×10−2) |