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Table 2 For each dataset of [ 38 ], the estimated r and π 0 from CisGenome (columns 2 and 3), from NCIS (columns 4 and 5), and from CCAT (columns 6 and 7)

From: Is this the right normalization? A diagnostic tool for ChIP-seq normalization

Dataset

CisGenome

NCIS

CCAT

 

\(\boldsymbol {\hat {r}}\)

\(\boldsymbol {\hat {\pi }_{0} = \frac {N_{\textit {in}}}{N_{\textit {ch}}}\hat {r}}\)

\(\boldsymbol {\hat {r}}\)

\(\boldsymbol {\hat {\pi }_{0} = \frac {N_{\textit {in}}}{N_{\textit {ch}}}\hat {r}}\)

\(\boldsymbol {\hat {r}}\)

\(\boldsymbol {\hat {\pi }_{0} = \frac {N_{\textit {in}}}{N_{\textit {ch}}}\hat {r}}\)

CTCF

0.6699

0.5633

0.6657

0.5598

0.6419

0.5397

H3K4me3

0.3833

0.3845

0.3751

0.3762

0.3715

0.3726

H3K27me3

0.6163

0.8929

0.5182

0.7507

0.5187

0.7515

H3K36me3-1

0.6460

0.7672

0.5727

0.6801

0.5689

0.6757

H3K36me3-5

0.7097

0.7058

0.6802

0.676

0.6763

0.6725

H3K36me3-8

0.6987

0.7154

0.6813

0.6976

0.6499

0.6654

H3K36me3-pooled

1.3117

0.4644

1.4680

0.5198

1.8084

0.6403

\(\frac {\hat {\pi }_{01}N_{Ch_{1}}+\hat {\pi }_{05}N_{Ch_{5}}+\hat {\pi }_{08}N_{Ch_{8}}}{N_{Ch_{1}}+N_{Ch_{5}}+N_{Ch_{8}}}\)

 

0.7274

 

0.6848

 

0.6710

  1. The last row shows an estimate of π 0 for the pooled sample (modification H3K36me3) based on a weighted average of the three estimated π 0 in the three individuals samples.