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Figure 1 | BMC Bioinformatics

Figure 1

From: NetCooperate: a network-based tool for inferring host-microbe and microbe-microbe cooperation

Figure 1

A schematic illustration of the Biosynthetic Support score and Metabolic Complementarity Index. (A) In this toy example, the blue bacterium represents a parasite that is supported by the red eukaryotic host. The metabolic networks of both species are shown. Seeds are colored red, whereas potential products are colored orange. In this example, the bacterium has 2 seed groups: A and F/G/H, both of which can be supported by the host metabolic network (grey arrows). Accordingly, the BSS of the host on the parasite is 1.0. (B) In this toy example of two interacting microbes, the complementation of the blue species by the red species is illustrated (for illustration purposes, the same metabolic networks as in panel A are used). The seed A of the blue species is a product of the red species and can therefore be complemented (grey arrow). However, since F is a seed in both species, the red species cannot complement F for the blue species. The MCI of the red species on the blue species is therefore 0.5.

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