Figure 2

Alignment space and clustering. a. The log density plot of all neurite-derived sequences on the first two dimensions of alignment space suggests differentiable groups. b. Clustering of the alignment space reveals four clusters associated with dendrites (blue), two associated with axons (magenta), and one associated with apical dendrites (green); most neurites grouped with the cluster associated to their arbor types, but some classified with another cluster (gray). Ellipses reflect the covariance matrices of the cluster models. c. Sub-clustering of apical dendrites yields additional spherical clusters that associate with neocortex (cyan - top), hippocampal CA1 (green - right), and hippocampal CA3 (yellow - left). Apical dendrites improperly classified have lower color intensity. d. Unsupervised model-based clustering of the alignment space classifies CA1 and CA3 apical dendrites with an adjusted Rand Index of 0.72. A trained linear discriminant analysis achieves 94% accuracy.