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Figure 5 | BMC Bioinformatics

Figure 5

From: Topological characterization of neuronal arbor morphology via sequence representation: II - global alignment

Figure 5

Multiple sequence alignment and consensuses. a. Sequences of axonal cluster 2 (left) are aligned (right). A section of the alignment is magnified along with the composite and consensus (bottom). A single neurite in the cluster and its sequence in the MSA is highlighted (green). b, d. Consensuses of axon clusters 3 (b, blue) and 4(d, red) in sequence and dendrogram form, with relative length and average conservation statistics. Dendrogram branch width indicates conservation of the parent bifurcation (from 0.5 to 1). Branch length indicates variability preceding a bifurcation, calculated as the average proportion of a sequence falling between conserved bifurcations. c, e. Example morphologies and dendrograms of cluster 3 (c) and 4 (e) (NMO_02624, 00427, 07447, 00332 from [41,63,65]). Colored segments indicate an alignment with the consensus at the bifurcation. Black and gray segments indicate consensus bifurcations not found in the neurite and vice versa.

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