Skip to main content

Advertisement

Fig. 2 | BMC Bioinformatics

Fig. 2

From: Error correction and statistical analyses for intra-host comparisons of feline immunodeficiency virus diversity from high-throughput sequencing data

Fig. 2

Histograms and simulated distributions; library pairs. Histograms represent empirical distributions for minor allele (i.e. substitution) frequencies for 6 library pairs, which are derived by pooling minor allele frequencies of the two replicates for each of 6 “treatment” conditions (tissue by infection status) represented by the 12 libraries. Dashed curves represent distributions simulated from exponential-normal convolution models with parameter values estimated for each library pair (Table 1). Solid curves represent distributions simulated from the same models with parameters estimated on the library pair 1 and 2 (Table 1) appropriately “spiked” with low frequency substitutions (see insets) to account for their abundance in high coverage sequencing data. Note that for the pair 1 and 2, where coverage is lowest, dashed and solid curves are undistinguishable. The differences between the two curves are largest for pairs with highest coverage (see Table 1)

Back to article page