Weighted protein residue networks based on joint recurrences between residues

BMC Bioinformatics

Table 2 Betweenness centrality and closeness centrality results for significant nodes in the CSU-weighted network

Centrality	Residue	RSA	Significant neighbors
Betweenness	9	0.06	Ammonium and Sulfate ion binding site, 71(C6)
-	41(C5)	0.03	36(C5), 53(C5)
-	53(C5)	0.22	41(C5), 112(C4)
-	73	0.24	53(C5), 74(C2), 112(C4), 143(C2)
-	112(C4)	0.28	53(C5), 71(C6), 148(C3)
-	114	0.20	Sulfate ion binding site
-	148(C3)	0.15	112(C4), 143(C2), 150(C3), 160(C3), 162(C4)
Closeness	9	0.06	71(C6), Ammonium and Sulfate ion binding sites
-	53(C5)	0.22	41(C5), 112(C4)
-	70 (Sulfate ion binding site)	0.04	112(C4), 71(C6), Sulfate ion binding site
-	71(C6)	0.22	53(C5),112(C4), 113(C6), Sulfate ion binding site
-	72	0.02	53(C5), 71(C6), 74(C2), 112(C4)
-	73	0.24	53(C5), 74(C2), 112(C4), 148(C3)
-	74(C2)	0.13	143(C2)
-	111	0.22	112(C4), Sulfate ion binding site
-	112(C4)	0.28	53(C5), 71(C6), 148(C3)
-	113(C6)	0.26	112(C4), 71(C6), sulfate ion binding site
-	114	0.20	Sulfate ion binding site
-	143(C2)	0.22	74(C2), 142(C2), 148(C3)
-	148(C3)	0.15	112(C4),143(C3), 150(C3), 160(C3)

This table lists residues with betweenness centrality z-score values larger than 2 and closeness centrality values larger than 1.5. It also gives the relative solvent accessibility for each residue, and its first degree neighbors. The symbols between brackets denote hotspot clusters

ISSN: 1471-2105