Weighted protein residue networks based on joint recurrences between residues

BMC Bioinformatics

Table 3 Betweenness centrality and closeness centrality results for significant nodes in the JRP-weighted network

Centrality	Residue	RSA	Significant neighbors
Betweenness	5	0 .40	Ammonium ion binding site
-	50(C5)	0.35	36(C5), 41(C5), 49(C1)
-	66	0.47	-
-	68	0.10	Sulfate ion binding site
-	93	0.58	-
-	116	0.15	Sulfate ion binding site
-	122	0.67	-
-	140	0.58	74(C2)
-	141	0.39	74(C2), 142(C2), 143(C2)
-	152	0.34	-
-	162(C4)	0.42	148(C3), 150(C3), 160(C3)
-	163	0.67	142(C2)
-	164	0.05	-
Closeness	46	0.64	50(C5)
-	47	0.07	49(C1), 50(C5), 74(C2)
-	49(C1)	0.25	50(C5)
-	50(C5)	0.35	36(C5), 41(C5), 49(C1), 53(C5)
-	68	0.10	Sulfate ion binding site
-	116	0.15	Sulfate ion binding site
-	117	0.44	-
-	122	0.67	-
	140	0.58	74(C2)
	141	0.39	74(C2), 142(C2), 143(C2)
	142(C2)	0.86	143(C2)
	163	0.67	142(C2), 162(C4)

This table lists residues with betweenness centrality z-score values larger than 2 and closeness centrality values larger than 1.5. It also gives the relative solvent accessibility for each residue, and its first degree neighbors. The symbols between brackets denote hotspot clusters

ISSN: 1471-2105