Fig. 5

Ancestral relationships of the new GO terms created to support detailed ASD-relevant annotations in the domain of cell communication. A subsection of the ‘cell communication’ domain ontology, human protein families (blue ovals) and their associated GO terms (green boxes), linked with red dotted line (see Additional files 5 and 8); all associations (except IEA-supported data) are included. If one or several member(s) of a protein family is associated with a specific term then the family name, or the protein name DLG4, is listed below the term. * indicates new GO terms (Table 1). Black arrows indicate an ‘is_a’ relationship between a term and its parent; blue arrows, a ‘part_of’ relationship; yellow arrows, a ‘regulation’ relationship; green arrows, a ‘positive_regulation’ relationship