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Table 2 Biological process behavioral GO terms associated with the ASD-relevant human and mouse proteins

From: Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism

 

Human

Mouse

GO term name

NLGN3

NLGN4X

NLGN4Y

NRXN1-α

NRXN1-β

NRXN2-α

NRXN3-α

NRXN3-β

CNTNAP2

SHANK1

SHANK2

SHANK3

Nlgn2

Nlgn3

Nlgn4l

Nrxn1-α

Dlg4

Shank1

Shank2

Shank3

adult behavior

X

X

 

X

X

X

X

X

X

X

X

X

   

X

  

X

 

learning

X

X

X

X

X

 

X

X

X

 

X

X

   

X

  

X

X

social behavior

X

X

X

X

X

X

X

X

X

X

X

X

 

X

X

 

X

X

X

X

vocalization behavior

X

X

X

X

X

X

X

X

X

X

X

X

  

X

 

X

X

X

X

vocal learning

   

X

 

X

  

X

  

X

        

locomotory exploration behavior

            

X

   

X

  

X

visual learning

             

X

      

male courtship behavior

              

X

     

territorial aggressive behavior

              

X

     

regulation of grooming behavior

               

X

X

  

X

associative learning

                 

X

  

habituation

                 

X

  

long-term memory

                 

X

  

olfactory behavior

                 

X

  

memory

                  

X

X

exploration behavior

                  

X

 

regulation of behavioral fear response

                   

X

  1. X indicates the existence of an association between the GO term and the protein record, based on behavioral traits associated with variant genes only (IMP, Inferred from Mutant Phenotype, or IGI, Inferred from Genetic Interaction, supported annotations, see Additional files 5 and 8)