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Table 3 Program memory allocation and runtimes for pooled BAM files of 4, 8, and 16 ClinSeq samples, 35.1× average coverage each

From: Evaluation of variant detection software for pooled next-generation sequence data

Program CPU Hours per BAM file Memory Used/Provided
CRISP <2 h <150 Mb Used
SNVer 1 - 5 h 4 - 8 Gb Provided
LoFreq 1 - 5 h ~150 Mb Used
VarScan 2 - 5 h 6-8 GB Provided
GATK 8 h - +7 days 4 - 20 Gb Provided
  1. Java programs required users to specify memory restrictions. Programs written in C were memory efficient and ran relatively quickly
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