Fig. 6

Specificity performance for each edge-weighting metric and fragmentation scenario. Specificity performance of MCL on graphs weighted using each of the four metrics (columns) over a range of inflation parameter values (x-axes) in a variety of fragmentation scenarios (rows). Vertically stacked bars indicate the number of unique ECKs from which the members of a particular MCL cluster originated. Blue segments represent MCL clusters that contain sequences from only a single ECK. Other segments represent MCL clusters containing sequences from two or more ECKs, with redder color indicating higher degrees of contamination. A large number of “pure” clusters containing only a small portion of a particular ECK can appear desceptively good, so multiples of the desired 458 total clusters are indicated with dashed horizontal lines. Simulated fragmentation scenarios are as described in Fig. 5