Fig. 4

Transcription units called by groHMM using GRO-seq data from D. melanogaster and C. elegans. a Average gene densities for humans (H. sapiens), flies (D. melanogaster), and worms (C. elegans). b Transcript density plot for well-expressed transcription units identified by groHMM using optimal parameters. The number of well-expressed genes was 265, 4,524, and 2,060 for D. melanogaster, C. elegans, and H. sapiens, respectively. c Sample GRO-seq browser tracks for D. melanogaster. Transcription units called by groHMM using GRO-seq data are shown in comparison to RefSeq annotations. d Sample GRO-seq browser tracks for C. elegans. Transcription units called by groHMM using GRO-seq data are shown in comparison to RefSeq annotations. The gene density is much higher in worms compared to human and flies, resulting in longer groHMM-called transcription units, which merge several gene annotations