Fig. 1

Equalizer reduces SNP eQTL bias. a Schematic illustration of equalizer operation. b,c,d,e Histograms of mean effect of a single mouse FVB/N allele, calculated from the difference of mean expression levels for a given gene when divided by genotype at eQTL locus. At any given eQTL all mice will be either homozygous (FVB/N, FVB/N) or heterozygous (FVB/N, SPRET/Ei). A value greater than zero indicates mice homozygous for FVB/N alleles at that locus have higher expression levels. Histograms plotted for b M430 uncorrected skin, c Gene ST uncorrected mammary, d M430 corrected skin, and e Gene ST corrected mammary