Fig. 2

The effect of equalizer on eQTL results. a Plot of the change in eQTL statistical strength after correction vs. the uncorrected eQTL statistical strength for mouse mammary data. b, c Expression of Cdc26 at the cis-eQTL locus (b) before correction and (c) after correction, showing an increase in significance after correction. Expression levels are divided between homozygous (labeled FVB/FVB) and heterozygous (labeled FVB/SPR) genotypes, where FVB indicates FVB/N and SPR indicates SPRET/Ei. P values indicate linear regression, box and whiskers plots indicate median and first/third quartiles. d,e Plot of the change in eQTL statistical strength after correction vs. the uncorrected eQTL statistical strength for, (d) human EUR data and (e) human AFR data. f,g Expression of HLA-DPA1 in human AFR samples (f) before correction and (g) after correction, showing a decrease in statistical significance after correction. Expression labels are divided between the AA, AB, and BB versions of the rs1431400 genome variant. Plotted as 2b