Fig. 9

Ligand-binding/active site motifs at the N-terminus. Four motifs that represent ligand binding or active sites are shown, with example structures and global and peak-cluster (*) motif data (Abundance/Overrepresentation/Pvalue). Exemplar width is proportional to motif abundance in the corresponding cluster/geometry, while exemplar colour is proportional to overrepresentation. The CxxC motif (NCapC-N3C), which is involved in Zn binding and oxidation/reduction, shows distinct geometries for each function. Also shown is N”G-NCapG-N1K-N2T, which forms a “cradle” that binds phosphate/sulphate groups