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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Coevolutionary analyses require phylogenetically deep alignments and better null models to accurately detect inter-protein contacts within and between species

Fig. 1

Coevolution statistics differ in their ability to detect residue contacts in HisKA-RR sub-alignments. Direct methods benefit from larger, more diverse alignments. Left: Precision (PPV) at false positive rate (FPR) < 0.1 %. Right: Power (TPR) at false positive rate (FPR) < 5 %. Blue lines indicate a loess fit to each method, 95 % confidence intervals are shown in gray. See Abbreviations and Table 1 for abbreviations

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BMC Bioinformatics

ISSN: 1471-2105

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