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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Coevolutionary analyses require phylogenetically deep alignments and better null models to accurately detect inter-protein contacts within and between species

Fig. 4

Power (TPR), precision (PPV), and false positive rate (FPR) for predicting antiviral protein A3G residues (not pairs) essential for interacting with its viral antagonist Vif at P empirical <α thresholds that maximize PPV for each coevolution method. Residues defined as positive are taken from previous functional mutation studies in Table 3. See Abbreviations and Table 1 for abbreviations

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