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Fig. 4 | BMC Bioinformatics

Fig. 4

From: diffHic: a Bioconductor package to detect differential genomic interactions in Hi-C data

Fig. 4

Effect of normalization for CNV-based biases. Each log2-FC is defined as that between one ERG library over one GFP library in the Rickman et al. data set [5], adjusted for library size. To simplify visualization, the two marginal log-FCs for each bin pair are summed together. The depth of colour in the plot is proportional to the density of bin pairs, using only those retained after filtering. Results are shown before (a) and after (b) normalization for CNV-based biases

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