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Table 1 The top 5 statistically significant results of HBx aligned against EvoDB PFAM-A profiles

From: Robust sequence alignment using evolutionary rates coupled with an amino acid substitution matrix

PFAM ID

Description of family

BLOSUM-FIRE score

PID

dN/dS sim

Residues Matched

p-value

PF00739.14

Trans-activation protein X family.

0.62

76

0.49

113

0.0

PF05407.7

Rubella virus endopeptidase family.

0.49

20

0.77

33

7.62 × 10− 5

PF10895.3

Hydrophobic abundant protein (HAP) family.

0.48

18

0.77

27

2.28 × 10− 4

PF03866.8

RimK-like ATP-grasp domain family.

0.47

18

0.76

29

3.81 × 10− 4

PF05417.6

Protein of unknown function (DUF2715).

0.46

25

0.67

41

6.85 × 10− 4

  1. PFAM ID is the accession number of the PFAM family, BLOSUM-FIRE score is the algorithm score, PID is the percentage identity score of the aligned sequences, dN/dS sim is the similarity of the dN/dS values (old FIRE algorithm score) and residues matched is the number of identical amino acid matched