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Table 1 The top 5 statistically significant results of HBx aligned against EvoDB PFAM-A profiles

From: Robust sequence alignment using evolutionary rates coupled with an amino acid substitution matrix

PFAM ID Description of family BLOSUM-FIRE score PID dN/dS sim Residues Matched p-value
PF00739.14 Trans-activation protein X family. 0.62 76 0.49 113 0.0
PF05407.7 Rubella virus endopeptidase family. 0.49 20 0.77 33 7.62 × 10− 5
PF10895.3 Hydrophobic abundant protein (HAP) family. 0.48 18 0.77 27 2.28 × 10− 4
PF03866.8 RimK-like ATP-grasp domain family. 0.47 18 0.76 29 3.81 × 10− 4
PF05417.6 Protein of unknown function (DUF2715). 0.46 25 0.67 41 6.85 × 10− 4
  1. PFAM ID is the accession number of the PFAM family, BLOSUM-FIRE score is the algorithm score, PID is the percentage identity score of the aligned sequences, dN/dS sim is the similarity of the dN/dS values (old FIRE algorithm score) and residues matched is the number of identical amino acid matched