Fig. 5
From: Amplitude spectrum distance: measuring the global shape divergence of protein fragments
Disagreements with TM-score: scores computed on the whole fragments and best manual (sub)alignment shown above. a Astral identifiers d1b71A_ residues 124:144 (in red) and d1psA_ residues 113:133 (in green) are similar for ASD (562) but not for TM-score (0.44). b Astral identifiers d1fha__ residues 109:129 (in red) and d1rcd_ residues 102:122 (in green) are similar for TM-score (0.60) but not for ASD (2995), in manual alignment, 14 residues over 20 are aligned. c Astral identifier d1amk_, residues 136:156, in red, and d1tri_ residues 126:146 are examples of similar fragments correctly scored by both ASD and TM-score that the heuristic of Fr-TM-align fails to align: TM-score on whole fragments is 0.7, while Fr-TM-align returns a TM-score of 0.27 by aligning only 11 residues