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Fig. 8 | BMC Bioinformatics

Fig. 8

From: CoSREM: a graph mining algorithm for the discovery of combinatorial splicing regulatory elements

Fig. 8

Possible combinatorial effect of the overlapped SREs (G G G A G G A,G A G G A C). One possible scenario is having SF2/ASF splicing factor with great affinity. It binds to the ESE and stimulate exon inclusion. Another possibility is if the splicing repressor hnRNP A1 exists, it may inhibit the exon inclusion by binding to the silencer sequence and recruit the binding of other inhibitory factors which extend to the exon boundary and prohibit the binding of the SF2/ASF protein. As a result, the exon will be skipped. The rectangles in this figure represent exons and lines represent introns

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