Fig. 3
From: Prior knowledge driven Granger causality analysis on gene regulatory network discovery
The five-variable model (a) was previously used in several studies [13, 24] to evaluate the performance of different gene regulatory network inference methods. However, it lacks the hierarchical modularized structure described in the real biological regulatory networks [35–37]. In this study, we generated a simulated hierarchical modularized network based on the 1 →3→9 module and the random perturbations (b). a Five-variable model. b Modularized hierarchical model