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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Predicting protein function via downward random walks on a gene ontology

Fig. 1

An example of a partially annotated protein. The GO terms in the white ellipses are the currently available functions of the protein, and the terms in the colored ellipses are the missing functions of the protein. In particular, the terms in the grey ellipses are missing functions of the first type: they are associated with other proteins, but are missing for the protein being considered. The terms in the blue ellipses belong to the second type: they exist in the GO hierarchy, but they are not associated with any protein of interest. We observe that any missing function of a protein should be a leaf node of the hierarchy, and this hierarchy is defined with respect to the available terms associated with the protein, rather than with the whole GO hierarchy. We can replenish a non-leaf term of a protein directly using its descendant terms, due to the true path rule of GO

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