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Table 3 List of key parameters used in the Prokaryo model: parameter values have been set in order to replicate experimental data as reported from wet lab experiments and in the literature [1]

From: PROKARYO: an illustrative and interactive computational model of the lactose operon in the bacterium Escherichia coli

Parameter

Description

Value

n

Nucleotides per unit

3

Tr

Transcription speed

60 base pairs per second

Gt

Glucose threshold

40000 count per bacterium

Ro

Ribosome offset

0.1

Tf

Translation frequency

0.25 s e c −1

Rd

Ribosome dock delay

1.0 s e c −1

Ptc

Protein threshold count

3.0

Rlt

Repressor lactose threshold

2000 cpb

Ta

Transcription affinity

0.01

St

simulation time factor

10