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Table 4 Performance of RUV-random when biological signal and systematic noise are differently correlated (based on 1000 simulation runs)

From: Systematic noise degrades gene co-expression signals but can be corrected

Average Cor(W,X)

% WS

FN2

0.1127

8.3

0.138

0.1634

14.5

0.211

0.2015

21.6

0.281

0.2341

27.7

0.341

  1. The performance was measured using the percentage of estimates with the wrong sign (WS). While FN2 refers to a squared Frobenius norm (FN2) measure (explained in the text), which should be close to 0. All parameter choices and details of the simulation can be found in Additional file 1. All standard deviations for FN2 were <0.001