Fig. 3

Comparison of five DNA motifs using DiffLogo. Comparison of five CTCF motifs from cell lines H1-hESC, MCF7, HeLa-S3, HepG2, and HUVEC. We plot all pair-wise sequence logos and display the distance between each motif using the background color from green (similar) to red (dissimilar). We plot the sequence logos of each motif as well as the leaf-ordered cluster tree above. The motifs of H1-hESC and MCF7 are highly similar and substantially different from the other motifs, while the motifs of HeLe-S3, HepG2, and HUVEC are similar to each other as well. Due to leaf ordering, the difference between compared motifs increases with increasing distance from the main diagonal in the difference logo grid