Fig. 5

Results of subregion registration of random cutouts. Yellow rectangles indicate the ground truth registration location, black rectangles indicate the registration result. Results of subregion registration of random cutouts in (a) cutouts of size 180×320 pixel spectra in sample S6; (b) cutouts of size 360×640 pixel spectra in S6. Panel (c) shows Subregion registration using of our pipeline (84 regions registered correctly). Panel (d) shows registration results of the binary MS/evo approach for the same 100 random cutouts (32 regions registered correctly). A corresponding comparison involving further methods and random cutouts of three samples is shown in Additional file 2: Table S1